
Kabavir-L is a famous brand of Abacavir Sulphate and Lamivudine . This combination product is antiviral for human immunodeficiency virus from multiplying in the body’s functions. Ingredients are nucleoside analogue reverse transcriptase inhibitors. It is a type of antiviral similar to antiretrovirals.
They are NRTIs, Intracellular kinases metabolise both sequentially to their respective 5’-triphosphates. They function as anti HIV reverse transcriptase inhibitors. Both compositions lower the compatibility for host cell deoxyribonucleic acid polymerase.
Like purine guanine, Abacavir is a synthetic carbocyclic nucleoside analogue. Intracellular enzymes phosphorylate and deaminate it in various phases to produce the metabolite with activity triphosphate. It is an analogue of deoxyguanosine-5-triphosphate. This conflicts with endogenous Deoxyguanosine Triphosphate and discourages its incorporation into HIV viral DNA. This stoppage of chain elongation inhibits viral proliferation.
Like purine guanine, Abacavir is a synthetic carbocyclic nucleoside analogue. Intracellular enzymes phosphorylate and deaminate it in various phases to produce the metabolite with activity triphosphate. It is an analogue of deoxyguanosine-5-triphosphate. This conflicts with endogenous Deoxyguanosine Triphosphate and discourages its incorporation into HIV viral DNA. This stoppage of chain elongation inhibits viral proliferation.
The enzyme-nucleoside-diphosphate kinase converts diphosphates to triphosphates. Subsequently, the process phosphorylates. The primary mode of action inhibits HIV reverse transcription by terminating viral DNA chains. They work against HIV reverse transcriptase by acting as opposing inhibitors.
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Abacavir Sulphate-600mg and Lamivudine-300mg