Ziovir-L

Ziovir-L

Ziovir-L is a combination of Tenofovir and Lamivudin, a combination of antiretroviral medicine for Human immunodeficiency virus and hepatitis B virus. They are part of more substantial regimen which involves antiretroviral medications. These function by slowing the progression of HIV inside the body.  Even so, they might decrease the chance of HIV-related illnesses including acquired immunodeficiency syndrome.

Tenofovir fumarate act as a nucleotide reverse transcriptase inhibitor, on other side, lamivudine is a nucleoside reverse transcriptase. Lamivudine generates active metabolites upon phosphorylation, which compete with it for incorporation into viral DNA. Its metabolites completely inhibit the activity of HIV back transcriptase enzyme through DNA incorporation and act as a chain terminator of deoxyribonucleic acid synthesis. Because of the lack of 3’-OH group, included nucleoside analogues discourage the formation of phosphodiester linkage, which is required for DNA chain extension.

K65R mutation in HIV back transcriptase impacts the phenotypic susceptibility to medicine combination. Even though researchers rarely elect the k65R mutation in comparison to the thymidine analogue mutations.

Overlapping resistance characteristic, variable medication absorption into cells, esterase cleavage of TDF, and interaction at the influx transport level may all contribute to resistance development. NRTIs is antiviral which involve intracellular phosphorylation to function properly. As a result, cell is critical for effective viral replication inhibition. Protein binding, iron trapping, Lipophilicity, and pill transporters all contributes to intercellular accumulation. One or more of the nucleoside transporter systems, including concentrative, equilibrate, and h+ peptides, usually transmit most nucleoside analogs.

Antiretroviral Products Manufacturer

Ziovir-L is an anti-HIV medicine, that is manufacture by Sunrise Remedies Pvt. Ltd. Human immunodeficiency virus medications are referred to as "antiretroviral." Compositions works as per anatomy requirement and structure. NRTIs, Non NRTIs and other ingredients function individually with different stages structure. This medication is oral and come with two combined compositions.

• COMPOSITION
• MODE OF USE
• WARNINGS