Zidosun-L
Zidosun-L
Zidosun-L is a mixed generic of Zidovudine 300 and Lamivudine 150 mg. HIV reverse transcriptase, the enzyme that human immunodeficiency virus utilizes to create a DNA copy of its RNA, is inhibited by these compositions, which are long-standing nucleoside reverse transcriptase inhibitors. Although they lack 3’ hydroxyl group required for further development, they interact with normal nucleosides for acceptance into the expanding viral DNA chain and subsequently disrupt the chain.
Both medicines have pharmacologic chemical action; they may phosphorylate intracellularly to the triphosphate anabolite. Inhibiting human immunodeficiency virus-deoxyribonucleic acid synthesis, a vital and essential phase in the viral replication cycle. The significantly conserved element among retroviruses is reserve transcriptase. The structural active form of zidovudine is the intracellular triphosphate anabolite.
In addition to dephosphorylation medicine-phosphates in the medication, phosphatases are broad-spectrum dephosphorylation enzymes.
Both zidovudine and lamivudine selectively obstruct and decrease RT activity, which causes HIV-infected cells to lower the quantity of virus in the body. As nucleoside analogues, they function as substrates for human nucleoside kinases.
Intracellular level of naturally occurring thymidine triphosphate and decline as a result of the compound’s interaction with it for RNA-directed DNA polymerase. Lamivudine, on the other hand, may lower blood levels of hepatitis B and HIV. Increase CD4+ counts in cells. Also know that as T helper cells. It is an essential white blood cell for the immune system's operation. Lamivudine triphosphate and monophosphate forms play a key role in inhibiting viral deoxyribonucleic acid synthesis.
Antiretroviral Therapy for HIV Infection
There are many different types of antiretroviral therapies classified, including nucleotide and non-nucleotide reverse transcriptase, protease, entry, and integrase inhibitors. HIV may infect other cells in the body by making new copies of itself inside the infected cells and impact the immune system. This medication slows down replication by standing in the way of its replication process.
Zidovidine-300 mg and Lamvudine-150 mg Tablet